Nate founded XLEAR Inc. in 2000, long before Covid-19.

He has been an advocate for the importance of basic hygiene in maintaining health, a fundamental principal of disease prevention.

During Covid-19, he noted that studies linked severe (often deadly) cases of Covid to patients with poor dental health. Together with dental health, he noted nasal hygiene also reduced the risks of infection or severity of the illness. He worked with others to petition the CDC to issue guidance on nasal hygiene. The CDC rejected this petition. In 2022, a clinical trial of healthcare workers using nasal hygiene reduced their risk of infection by 62%. In response to his work, the Federal Trade Commission sued him.